ISO 19290:2021

Current Revision
Cigarettes - Determination of tobacco specific nitrosamines in mainstream cigarette smoke - Method using LC-MS/MS

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ISO 19290:2021

Cigarettes - Determination of tobacco specific nitrosamines in mainstream cigarette smoke - Method using LC-MS/MS

PUBLISH DATE 2021
ISO 19290:2021

This document specifies a method for the quantification of four tobacco specific nitrosamines (TSNAs) in the total particulate matter of mainstream cigarette smoke by using reversed phase high performance liquid chromatography with tandem mass spectrometry (LC-MS/MS).

The quantified TSNAs are:

  • N-nitrosonornicotine (NNN),
  • N-nitrosoanatabine (NAT),
  • N-nitrosoanabasine (NAB) and
  • 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
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