ISO 23921:2020

Current Revision
Cigarettes - Determination of tobacco specific nitrosamines in mainstream cigarette smoke with an intense smoking regime - Method using LC-MS/MS

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ISO 23921:2020

Cigarettes - Determination of tobacco specific nitrosamines in mainstream cigarette smoke with an intense smoking regime - Method using LC-MS/MS

PUBLISH DATE 2020
ISO 23921:2020

This document specifies a method for the quantification of four tobacco specific nitrosamines (TSNAs) in the total particulate matter of cigarette mainstream smoke with the intense smoking regime specified in ISO 20778 by using reversed phase high performance liquid chromatography with tandem mass spectrometry (LC-MS/MS).

The quantified TSNAs are: N-nitrosonornicotine (NNN), N-nitrosoanatabine (NAT), N-nitrosoanabasine (NAB) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

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