ISO 5725-3:2023

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Accuracy (trueness and precision) of measurement methods and results - Part 3: Intermediate precision and alternative designs for collaborative studies

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Accuracy (trueness and precision) of measurement methods and results - Part 3: Intermediate precision and alternative designs for collaborative studies

PUBLISH DATE 2023

This document provides:

  • a) a discussion of alternative experimental designs for the determination of trueness and precision measures including reproducibility, repeatability and selected measures of intermediate precision of a standard measurement method, including a review of the circumstances in which their use is necessary or beneficial, and guidance as to the interpretation and application of the resulting estimates, and
  • b) worked examples including specific designs and computations.

Each of the alternative designs discussed in this document is intended to address one (or several) of the following issues:

  • a) a discussion of the implications of the definitions of intermediate precision measures;
  • b) a guidance on the interpretation and application of the estimates of intermediate precision measures in practical situations;
  • c) determining reproducibility, repeatability and selected measures of intermediate precision;
  • d) improved determination of reproducibility and other measures of precision;
  • e) improving the estimate of the sample mean;
  • f) determining the range of in-house repeatability standard deviations;
  • g) determining other precision components such as operator variability;
  • h) determining the level of reliability of precision estimates;
  • i) reducing the minimum number of participating laboratories by optimizing the reliability of precision estimates;
  • j) avoiding distorted estimations of repeatability (split-level designs);
  • k) avoiding distorted estimations of reproducibility (taking the heterogeneity of the material into consideration).

Often, the performance of the method whose precision is being evaluated in a collaborative study will have previously been assessed in a single-laboratory validation study conducted by the laboratory which developed it.

Relevant factors for the determination of intermediary precision will have been identified in this prior single-laboratory study.

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