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BSI BS ISO 19040-3:2018

Water quality. Determination of the estrogenic potential of water and waste water -- In vitro human cell-based reporter gene assay
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BSI BS ISO 19040-3:2018

Water quality. Determination of the estrogenic potential of water and waste water -- In vitro human cell-based reporter gene assay

PUBLISH DATE 2018
PAGES 48
BSI BS ISO 19040-3:2018

This document specifies a method for the determination of the estrogenic potential of water and waste water by means of a reporter gene assay utilizing stably transfected human cells. This reporter gene assay is based on the activation of the human estrogen receptor alpha.

This method is applicable to:

  • fresh water;

  • waste water;

  • aqueous extracts and leachates;

  • eluates of sediments (fresh water);

  • pore water;

  • aqueous solutions of single substances or of chemical mixtures;

  • drinking water;

  • the limit of quantification (LOQ) of this method for the direct analysis of water samples is between 0,3 ng/l and 1 ng/l 17β-estradiol equivalents (EEQ) based on the results of the international interlaboratory trial (see Annex F). The upper working range was evaluated [based on the results of the international interlaboratory trial (see Table F.3)] up to a level of 75 ng EEQ/l. Samples showing estrogenic potencies above this threshold have to be diluted for a valid quantification. Extraction and pre concentration of water samples can prove necessary if their estrogenic potential is below the given LOQ.

SDO BSI: British Standards Institution
Document Number ISO 19040-3
Publication Date Aug. 10, 2018
Language en - English
Page Count
Revision Level
Supercedes
Committee EH/3/5
Publish Date Document Id Type View
Oct. 31, 2022 BS EN ISO 19040-3:2022 Revision
Aug. 10, 2018 BS ISO 19040-3:2018 Revision